Training & Employment Opportunities
Almost all Post Doctoral Trainees and Research Scientists from the John Lab have continued to faculty positions, with others continuing to careers of their choice. Our Research Assistants have continued to top Ph.D. and medical programs. For those who seek continued research training and scientific development, we offer unique training opportunities in mouse genetics, ocular disease, ocular pathology, and the general use of mice for studying disease mechanisms. Research Scientist positions typically follow postdoctoral training and are suited to highly productive and dedicated individuals who are able to contribute at a high level, but want to spend more time at the bench, either as long-term lab members or as a stepping-stone to becoming PIs.
We are currently recruiting for various research assistant and related positions, which are posted below along with the application link for document submission.
In addition to any listed positions, the John Lab is always interested in well-qualified applicants. Although such positions are not currently posted, we can consider qualified individuals and expect to open new postings in the near future . We are especially interested in a microscopy/imaging specialist and in postdoctoral fellows and research scientists with interest in the following areas:
1. Aqueous humor dynamics and IOP elevation with a focus on applying modern approaches to the trabecular meshwork and Schlemm's canal (in normal and mutant animals as well as in mouse and human cell lines and organ culture). Projects will include single cell and other genomic, transcriptomic and metabolic experiments to better understand the molecular control of aqueous humor drainage and how IOP becomes elevated with age and in glaucoma. Using animal models, we plan to molecularly define cell types and determine their roles in IOP elevation/glaucoma as well as develop gene therapies and other treatment modalities. We are very interested in the effects of immune cells on IOP. We are also defining the developmental and transcriptomic sequences that control the formation of the ocular drainage tissues.
2. Functional morphology of the ocular drainage pathways. This effort will closely integrate with other trabecular meshwork and Schlemm's canal studies, but with emphasis on microanatomy and changes with differing pressures. We will use recent microscopic innovations (in confocal microscopy, 3D EM, imaging etc.) to characterize the functional anatomy of the drainage tissues and to determine the roles of specific molecules in defined cell types and processes. The project is well suited to a passionate, innovative microscopist with experience in rendering large datasets in 3D and interest in biological mechanisms.
3. RGC and optic nerve degeneration in glaucoma. We are interested in the roles of specific cell types including vascular cells in glaucoma and how aging and metabolic changes modulate vulnerability to glaucoma. Projects include the study of axon degeneration pathways, determining how metabolism changes with age and glaucoma, and the development of resilience boosting treatments that enhance cellular bio-energetics and anti-stress processes, as well as tailored gene therapies. Projects will include data science/computational expertise to analyze single cell and other genomic and metabolic data to better understand these processes using various glaucoma models.
Some combination of the following expertise are desirable for these projects: contemporary transcriptomics, metabolomics, metabolism, NAD metabolism, mitochondrial biology and assays, aging, neuroinflammation, monocyte/macrophage biology, mechanotransduction, iPS cells, molecular biology, vascular biology, ChIP seq, viral vectors, gene therapy, genetics, ocular fluid physiology and data science/computational expertise to analyze large datasets. We are particularly eager to recruit top candidates with 1) deep expertise in metabolism/metabolomics and aging, 2) Viral vectors, tropism and gene regulation or 3) strong experience in omic data generation and/or skills in computational data analyses with proven ability to innovate and synergize with experimental biologists.
A complete application should include a cover letter, resume, and the contact information for three references. For Postdoctoral and Research Scientist positions a brief (2 to 3 page) summary of research experience and interests is also required. Applications should be sent to email@example.com in PDF format.
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Research Associate I
The following positions were recently filled, but we will soon post new openings that are similar.