Full list of journal publications 

Selected Publications

Balasubramanian R, Kizhatil K, Li T, Tolman N, Bhandari A, Clark G, Bupp-Chickering V, Kelly RA, Zhou S, Peregrin J, Simón M, Montgomery C, Stamer WD, Qian J, John SWM. Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states. 2024. eLife 13:RP96459

Tolman NG, Balasubramanian R, Macalinao DG, Kearney AL, MacNicoll KH, Montgomery CL, de Vries WN, Jackson IJ, Cross SH, Kizhatil K, Nair KS, John SWM. Genetic background modifies vulnerability to glaucoma-related phenotypes in Lmx1b mutant mice. 2021. Dis Model Mech 14 (2): dmm046953

Harder JM, Guymer C, Wood JPM, Daskalaki E, Chidlow G, Zhang C, Balasubramanian R, Cardozo BH, Foxworth NE, Deering KE, Ouellette TB, Montgomery C, Wheelock CE, Casson RJ, Williams PA, John SWM. 2020. Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin. Proc Natl Acad Sci U S A 117(52):33619-33627

Williams PA, Harder JM, Foxworth NE, Cochran KE, Philip VM, Porciatti V, Smithies O,  John SWM. 2017. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science 355(6326):756-760

Harder JM, Braine CE, Williams PA, Zhu X, MacNicoll KH, Sousa GL, Bucahanan RA, Smith RS, Libby RT, Howell GR, John SWM. 2017. Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective. Proc Natl Acad Sci U S A  114(19):E3839-E3848  

Howell GR, MacNicoll KH, Braine CE, Soto I, Macalinao DG, Sousa GL, John SWM. 2014. Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma. Neurobiol Dis 11 (71):44-52

Kizhatil K, Ryan M, Marchant J, Henrich S, John SWM. 2014. Schlemm’s canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process. PloS Biol  12(7):e1001912

*Howell GR, Soto I, Zhu X, Ryan M, Macalinao DG, Sousa GL, Caddle LB, MacNicoll KH, Barbay JM, Porciatti V, Anderson MG, Smith RS, Clark AF, Libby RT, John SWM. 2012. Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma. J Clin Invest 122(4):1246-61.  *Lewis Rudin Glaucoma Prize for outstanding glaucoma paper in 2012                                                                                           

Nair KS, Hmani-Aifa M, Ali Z, Kearney A, Salem SB, Macalinao DG, Cosma IM, Bouassida W, Hakim B, Benzina Z, Soto I, Söderkvist P, Howell GR, Smith RS, Ayadi H, John SWM. 2011. Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalamia in humans and mice. Nat Genet 43(6):579-584

*Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai ACH, Nair KS, Cosma MI, Smith RS, Hodges E, AlFadhli SM, Al-Hajeri A, Shamseldin HE, Behbehani AM, Hannon GJ, Bulyk ML, Drack AV, Anderson PJ, John SWM**, Maas RL**. 2011. Mutations in the RNA Granule Component TDRD7 Cause Cataract and Glaucoma. Science 331:1571-1576. **Joint corresponding authors *Highlighted paper, Faculty of 1000 Biology

Howell GR,  Macalinao DG,  Sousa GL, Walden M, Soto I, Kneeland SC, Barbay JM, King BL, Marchant JK, Hibbs M, Stevens B, Barres BA, Clark AF, Libby RT, John SWM. 2011. Molecular clustering identified complement and endothelin induction as early events in a mouse glaucoma. J Clin Invest 121:1429-1444

Howell GR, Libby RT, Jakobs TC, Smith RS, Phalan FC, Barter JW, Barbay JM, Marchant JK, Mahesh N, Porciatti V, Whitmore AV, Masland RH, John SWM.  2007.  Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol  179:1523-1537

*Gould DB, Phalan FC, van Mil SE, Sundberg JP, Vahedi K, Massin P, Germaine Bousser M, Heutink P, Miner JH, Tournier-Lasserve E, John SWM.  2006.  Role of COL4A1 in small-vessel disease and hemorrhagic stroke. N E J Med 354:1489-1496  *Highlighted paper, Faculty of 1000 Biology

Libby RT, Yan L, Savinova OV, Barter J, Smith RS, Nickells RW, John SWM.  2005.  Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage.  PLoS Genet 1:17-26

*Gould DB, Phalan FC, Breedveld GJ, van Mil SE, Smith RS, Schimenti JC, Aguglia U, van der Knaap MS, Heutink P, John SWM.  2005.  Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly.  Science 308:1167-1171   *Highlighted paper, Faculty of 1000 Biology

*Anderson MG, Libby RT, Gould DB, Smith RS, John SWM.  2005.  High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma.  Proc Natl Acad Sci USA 102:4566-4571. * World-wide glaucoma award for daring, breakthrough, creative, original body of work & for most important paper in glaucoma in 2005.

Mo JS, Anderson MG, Gregory M, Smith RS, Savinova OV, Serreze DV, Ksander BR, Streilein JW, John SWM.  2003.  By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma.  J Exp Med 197: 1335-1344

*Libby RT, Smith RS, Savinova OV, Zabaleta A, Martin JE, Gonzalez FJ, John SWM.  2003.  Modification of ocular defects in mouse developmental glaucoma models by tyrosinase.  Science 299:1578-1581 *Lewis Rudin Glaucoma Prize, for most significant glaucoma paper in 2003

Anderson MG, Smith RS, Hawes NL, Zabaleta A, Chang B, Wiggs JL, John SWM.  2002. Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice.  Nat Genet 30:81-85

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